The strikes followed an attack hours earlier by members of Kataib Hezbollah and affiliated groups on Erbil air base in Iraq that injured three American service members, officials said.
The Pentagon said the airstrikes against facilities used by the Islamic Revolutionary Guards Corps and its proxies were in retaliation for recent rocket and drone attacks on American forces.
Two people were killed as security forces launched cross-border strikes at groups they accuse of fueling protests in Iran, which warned of more attacks.
The Revolutionary Guards Corps has been attacking Kurdish opposition groups in northern Iraq, blaming them for fomenting the unrest in Iran that was set off by the death of Mahsa Amini.